Faculty of Graduate Studies Online Theses
Recent Submissions
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DEVELOPING NATURAL KILLER T CELL BASED TOOLS AND STRATEGIES FOR TARGETING BREAST CANCER
Natural killer T cells are a rare population of immune-regulatory lymphocytes which have been implicated in tumor control. However, the benefit of NKT cell activation therapy in metastatic breast cancer remains poorly ... -
Interpretation of Aerosol Mass Scattering Efficiency over North America Using Ground Based Measurements from the IMPROVE Network
Aerosol mass scattering efficiency affects climate forcing calculations, atmospheric visibility, and the interpretation of satellite observations of aerosol optical depth. We evaluated the representation of aerosol mass ... -
Expanded insight into processing and isoform dependent properties of apelin
Apelin is one of two peptide ligands for a class A G-protein-coupled receptor (the apelin receptor; AR/APJ). Apelin-AR signalling regulates many body systems, including the cardiovascular system, central nervous system, ... -
The impact of long term testosterone withdrawal on cardiac excitation-contraction coupling in the mouse
The impact of chronic testosterone withdrawal on the structure and function of the heart was investigated in male C57BL/6 mice following bilateral gonadectomy (GDX) or a sham-operation at 4 weeks of age. In vivo ... -
Understanding the Nature of Aerobic Methane Emissions from Plants Grown under a Combination of Temperature, UVB Radiation and Watering Regime
Methane (CH4) is an important greenhouse gas besides carbon dioxide, nitrous oxide, water vapour, ozone, and chlorofluorocarbons. The atmospheric concentration of CH4 has nearly tripled since pre-industrial times. It is ... -
IMPACT OF MANGANESE ON CORROSION CONTROL AND BIOFILM FORMATION IN DISTRIBUTION SYSTEMS
The fate of manganese in distribution, along with its impact on biomass accumulation and lead release was investigated at the bench-scale. Confirmation of manganese-biofouling of the JD Kline Water Supply Plant’s raw water ... -
Proteomic and functional studies of the influenza A virus PA-X protein
Viral RNA endonuclease activity is required for influenza A virus (IAV) replication. This activity resides in the polymerase acidic (PA) protein, which assembles into viral RNA-dependent RNA polymerase (RdRp) complexes and ... -
Controlling Lead Release To Drinking Water: Impacts Of Iron Oxides, Complexing Species, Orthophosphate, And Lead Pipe Replacement
This work explored various approaches to controlling lead exposure via drinking water: orthophosphate treatment, limiting complexing or adsorbing species in distributed water, and lead service line replacement (LSLR). As ... -
Design-Build As An Approach for Community-Focused Projects: Building and Adapting in a Northern Community
This thesis focuses on creating and testing a design-build strategy for community-based projects. It poses questions on how to create work that is locally relevant, place sensitive and site specific in the contexts of ... -
IMPACT OF CUMULATIVE SLEEP RESTRICTION ON SLEEP PHYSIOLOGY IN CHILDREN WITH AND WITHOUT ATTENTION-DEFICIT/HYPERACTIVITY DISORDER (ADHD)
The impact of reduced sleep duration on sleep physiology has not been extensively studied in children. Children with attention-deficit/hyperactivity disorder (ADHD) may be particularly vulnerable to sleep loss as many of ... -
DEVELOPMENT AND ANALYSIS OF PATHWAYS TO NEW CONSTRUCTION NET-ZERO ENERGY HOUSES IN NOVA SCOTIA
17% of Canadian secondary energy consumption is consumed by the residential sector. Efforts to reduce this energy consumption and the associated emissions include the replacement of traditional housing with net-zero energy ... -
Enhancing the performance of multicast systems with layered transmissions
This dissertation advances the theory of multicast data distribution using layered division multiplexing within the framework of cooperative communications system design. Multicast services are an indispensable part of ... -
Predictors of Recurrence After the Surgical Correction of Exodeviation
Exodeviations are outward misalignments of the eyes, that may be characterized by periods of control and binocular vision. Despite the frequency of this diagnosis, treatment outcomes remain inconsistent. Surgery is one ... -
Quantifying Transport of Aquaculture Particulate Wastes
Scientific understanding of aquaculture interactions with the environment is limited, especially with regard to the far-field transport and possible impacts of particulate wastes. Both modelling and field studies have ... -
Acoustic Backscatter from Phytoplankton
Methods for the detection and monitoring of phytoplankton are often limited by low temporal and spatial resolution. The use of a high-frequency broadband acoustic system could provide improvements both temporally and ... -
Environ(mental) Architecture: How Architecture Shapes Our Mental Health Through the Use of Public Space
This thesis examines the potential of architecture to improve mental health through the design of public space. To determine the programmatic needs of a site, this document uses a human perception framework to analyze the ... -
Cross-Cultural Landscapes: Integrating Islam into the Rural Canadian Vernacular
Canada is a country of immigrants. Over generations our iconic landscape has offered a focal point for integration and been an important symbol of our identity. Yet as new cultures integrate their identity often fluctuates ... -
IN SITU MEASUREMENTS BY INSTRUMENTED GREY SEALS (HALICHOERUS GRYPUS) REVEAL FINE-SCALE OCEANOGRAPHIC PROPERTIES AND ENVIRONMENTAL INFLUENCES ON MOVEMENT PATTERNS
The influence of oceanographic conditions on the movements of large marine predators has been demonstrated in diverse taxa. However, obtaining subsurface data that are spatio-temporally relevant to the decisions made by ... -
Regional Variations in the Molecular Structure and Mechanics of the Lumbar Intervertebral Disc Annulus
Despite the prevalence of lumbar intervertebral disc related pathologies, fundamental aspects of the structure and mechanics of healthy discs remain unexplored. Little is known about whether the collagen structure of the ... -
The Role of Stereopsis in Microsurgical Performance on the EYESi Ophthalmic Surgical Simulator
There remains a lack of objective evidence on whether stereopsis is necessary for an ophthalmic surgical career. The present study attempts to address this question by evaluating the surgical performance of subjects with ...
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