Browsing by Subject "apoptosis"

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The bitter taste receptor Tas2R14 is expressed in ovarian cancer and mediates apoptotic signaling

Martin, Louis Thomas Poirier

Bitter taste receptors (Tas2Rs) are a subfamily of G-protein coupled receptors expressed not only in the oral cavity but also in several extra-oral tissues and disease states. For example, mammary epithelial cells express ...
Oncogenic ras-induced downregulation of a pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells

Yoo, Byong Hoon; Rosen, Kirill V. (Journal of Biological Chemistry, 2011-11-11)

Resistance of carcinoma cells to anoikis, apoptosis that is normally induced by loss of cell-to-extracellular matrix (ECM) adhesion, is thought to be essential for the ability of these cells to form primary tumors, invade ...
The roles of cellular Inhibitor of Apoptosis Protiens 1 and 2 in the polarization of M1 and M2 macrophages

Lammie, Alixandra

This thesis examined the effects of genetic ablation of the anti-apoptotic protein cIAP2 and SMAC mimetic (LCL161)-induced cIAP1 and cIAP2 suppression on the polarization of pro-inflammatory (M1) and anti-inflammatory (M2) ...