Browsing by Subject "GPCR"
Now showing items 1-6 of 6
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The bitter taste receptor Tas2R14 is expressed in ovarian cancer and mediates apoptotic signaling
Bitter taste receptors (Tas2Rs) are a subfamily of G-protein coupled receptors expressed not only in the oral cavity but also in several extra-oral tissues and disease states. For example, mammary epithelial cells express ... -
The Chemerin Receptor GPR1 Signals Through a RhoA/ROCK Pathway and Contributes to Glucose Homeostasis in Obese Mice
(2015-04-02)Chemerin is an adipose-derived hormone that regulates adipose tissue development, immunity, metabolism, and glucose homeostasis. To date, all chemerin function has been attributed to activation of the G protein-coupled ... -
An examination of how Rab GTPases and molecular chaperones influence plasma membrane expression of chemokine receptor dimers
(2013-11-22)Signal termination processes of GPCRs are well established, unlike processes that regulate the assembly and intracellular trafficking of these signaling complexes. Bimolecular fluorescence complementation was used to ... -
Expression, Purification And Biophysical Characterization Of Large Fragments Of The Apelin Receptor Enabling Delineation Of A Juxtamembrane Helix With Amphipathicity Necessary For Plasma Membrane Localization.
The apelin receptor (AR or APJ) is a class-A G-protein coupled receptor (GPCR) activated by various isoforms of the peptide hormones apelin and, during embryonic development, apela. The apelin-AR system has been proposed ... -
Probing Membrane Catalyzed Apelin-Receptor Interactions by Fluorescence Spectroscopy
Apelin is a peptidic hormone that activates the class A G-protein-coupled apelin receptor. Apelin is found in several bioactive isoforms in the body, ranging from 13 to 55 amino acids in length. Only the C-terminal 12 amino ... -
Transmembrane Domains IV, V, VI, and VII Contribute to Human Angiotensin II Type 1 Receptor Homomer Formation
From schizophrenia to asthma, GPCRs have an important role in drug therapy. This work focuses on the AT1R; a GPCR with widespread use in the treatment of cardiovascular disease. Specifically, this work examines the structural ...
